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The drug comes against the flu?

To date, the following applies: Before the flu virus only protects a vaccination. It is too late, only bed rest helps, drinking tea and sweating. But perhaps it could soon be an effective drug.

Annually health organization (WHO) published estimates of world worldwide three to five million people to the flu. Up to 650,000 Infected die as a result of associated respiratory diseases.

A research team led by biomedical scientist Richard Plemper from Atlanta has now successfully tested an antiviral drug against flu – but so far only in animal studies in ferrets, as well as in the laboratory of respiratory mucosal tissues of humans.

The active ingredient called EIDD-2801 blocking an enzyme called RNA Polymerase, which plays an important role in the propagation of the genetic material of the virus. As a result, the active ingredient of mutations in the genome of the Virus. If enough mutations occur, the genome is ineffective and the Virus can no longer multiply. The doctors published their research results on may 23. October in the journal Science Translational Medicine.

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Effective against many virus strains

“The molecule is highly efficient against the flu,” said Dr. Plemper, who teaches at Georgia State University biomedical and EIDD-2801, together with colleagues from the Emory University has developed. “It has been tested on a wide range of flu strains, and, above all, it represents a high barrier, which can overcome the Virus barely.”

Among other things, the active substance was also tested against the swine flu Virus that broke out worldwide in 2009. Ferrets are similar to humans in their response to flu viruses. After treatment with the drug, they show significantly shorter fever curves than the animals in the comparison group.

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No resistance observed

In the case of previous anti-viral agents and there is always the Problem that the virus managed to evolve through Mutation, resistance to the drugs. Dr. Mart Toots, one of the main authors of the study, said now that the Virus is very hard to miss the new molecule.

“We have, to date, no specific resistance mutations have been identified,” said Toots. He was confident that “the genetic barrier to viral resistance is high”. The active ingredient have a “high clinical Potential as a flu drug, the next Generation”.

The doctors want to test the drug in the coming year, for the first time on people.

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