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CRISPR/Cas9: it Is the Genschere even better?

U.S. researchers have found a new method to make the Genschere safer. Your “Prime Editing” method not cut all the strands of DNA as in the past. Thus, fewer errors will remain.

The so-called Prime Editing method (PE), developed by researchers at the Broad Institute in Cambridge/USA, builds on the well-known Genschere CRISPR/Cas9.

PE is inserted in the location, individual building blocks of the genetic material (DNA) to exchange, delete, or create combinations of these changes.

Unlike the previous procedure, PE cuts, however, both strands of the DNA double helix, but only one. Thus, changes in the genetic make-up should be prevented, which occur in the wrong place, the researchers write in the 21st century. October in the trade publication Nature.

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Gene therapies for people with genetic diseases

They assert that the method should be able to correct up to 89 percent of all known human hereditary diseases – such as sickle cell anemia.

The method may find, for example, in the context of gene therapy application. This refers to the deliberate Introduction of genetic information into the diseased cells of living people.

The PE “a very promising approach for gene therapy is,” says Dr. Dirk Heckl, Professor of experimental Pediatrics at the Martin-Luther-University of Halle-Wittenberg. “The shown efficiency is amazing, and [could be] to the independent validation of a milestone on the way to the therapeutic application of the CRISPR technology in gene therapy approaches.”

Theoretically, the genetic material would be before the artificial insemination repair. But this is banned in most countries because it represents an intervention in the human germ line.

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Crispr – Revolution or a risk?

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Crispr – Revolution or a risk?

More likely to use in plant breeding

The PE-method will probably be found mainly in the plant breeding application and, perhaps, in animal breeding, where certain properties are pronounced to be.

“Just for plants, the technology appears to be particularly interesting,” says Dr. Holger Puchta. The Professor of molecular biology and biochemistry of plants at the Karlsruhe Institute for technology (KIT) has been working for a long time because, carefully planned changes into the genome to bring in.

PE could help “so, in fact, easier to obtain disease-resistant plants, or gluten-free plant products,” he says. This must be tested first.

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