Stem cell Transplantation in the context of a cancer treatment, although the HI-virus will disappear, but German researchers sound a note of caution: As in HIV therapy, stem cell Transplantation is not suitable.
No one wants to speak of “healing”, but nevertheless, the message was that for the second Time in a HIV-Patient after a stem cell transplant is virus-free, worldwide headlines.
Scientists had reported on Tuesday that a formerly HIV-positive patients 18 months after a special stem cell transplantation no viruses were detected. The lymph glands, cancer, Hodgin’s lymphoma, diseased man stem cells had been a bone marrow donor to be transplanted, which is due to a rare genetic mutation resistant to HIV infection. After this stem cell treatment of the “London Patient will show” no symptoms of HIV infection.
Genetic peculiarity of the stem cell donor
Crucial to the stem cell donor, in which the HI Virus can no immune cell to infect, because a gene mutation of the most of the HI-virus used Receptor on the surface of immune cells, the CCR5 Receptor, was defective and therefore is not functional. The HI-Virus uses this Receptor as a type of portal of Entry for infection of immune cells. Without the functioning of the Co-Receptor, this path remains denied.
A similar case had taken place 12 years ago. The “Berlin Patient” Timothy Ray Brown has applied since 2008 as the first and, to date, only one HIV infection for the healed man. The London Doctors treated the patients described according to the same principle as in the time of the Berlin colleagues at the Charité.
That there is now a second case has been included in the specialist world: “repeatability is a crucial criterion of the scientific evidence,” said the Director of the Department of Virology at the University hospital of Heidelberg, Hans-Georg Kräusslich. The second case show according to the President of the German society for infectiology (DGI), Gerd Fätkenheuer, that the cure of the Berlin patient was not a singular event, but, in principle, repeatable. It’ll give scientists a boost searched for for a cure of HIV-Infected and the number of treatment could also narrow down strategies.
German scientists sound a note of caution
“This is an encouraging sign, but not proof of cure”, as the Heidelberg virologist Hans-Georg Kräusslich. So a Baby in the United States have had a total of 27 months after treatment, no detectable amount of virus, then the Virus had occurred.
Gero guardian, had treated in 2008, the “Berlin patient”, Brown at the Charité hospital in Berlin, pointed out that some patients who had received the same treatment, had died of complications or relapse of their cancer.
The anti-retro viral therapy (ART) with drugs remains the only HIV treatment option
Also, in the future, the Transplantation of stem cells will be no Option for the cure of a HIV-infection. In the case of a stem cell therapy, it was a massive intervention that “would not be in the face of a generally well-tolerated and effective long-term antiviral therapy is acceptable, if he were not contraindicated for other medical reasons,” says Kräusslich. So patients had received in both cases, these stem cells therapy due to their cancer and not because of their HIV disease.
Worldwide, millions of HIV patients will be treated once more with an anti-retro viral therapy (ART), which frees you from the Aids Virus. The life-long intake of drugs that keep the Virus in check, is currently the only way to treat HIV.
Lengthy and tricky search for new HIV therapy
What are the methods for the treatment of HIV are successful in the end, it is still largely unclear. The focus of the science of non-functional CCR5 Receptor on the surface of immune cells. To the development of HIV therapies, the genetic material of cells in HIV could be changed-the patient to the variant, the resistance trigger. Is trying to destroy the Gene for the CCR5 Receptor, for example, with the Genschere CRISPR/Casc9 in the own stem cells of patients, so infectable immune cells from the stem cells of the Person to produce.
The focus of the non-functional CCR5 Receptor on the surface of immune cells
This ethically controversial – approach of the Chinese researchers He Jiankui followed by changes in the genetic material of embryos using Genome editing. He was with this Experiment, at the end of last year for a storm of indignation, and the Chinese leadership has tightened the rules for the whole of the genetic research in China dramatically.
Worldwide, nearly 37 million people are infected with the HIV Virus, but only 59 percent of them received antiretroviral therapy. Every year, about one Million HIV patients die of diseases which are associated with the Virus. And now, a new, against drug-resistant HIV is of concern to the experts more and more.
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Live and love with HIV: films on the subject of AIDSAward-winning: 120 BPM
In the past year, the Drama “120 BPM won” the “Grand Jury prize” at the world’s most important film festival in Cannes. Director Robin Campillo tells of the love of two young AIDS activists. The French Director is a sensitive and cinematically interesting approach to a difficult topic.
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Live and love with HIV: films on the subject of AIDSFirst of all, serene: Sorry Angel
Campillos country man Christophe Honoré, the most recent Film on the topic of AIDS, “Sorry Angel” celebrated at the film festival in Cannes (2018) world premiere. The Film tells of the friendship of two gay men at the beginning of the 1990s in France. Honoré also deals in novels and theater pieces with the theme.
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Live and love with HIV: films on the subject of AIDSDisplacement: Longtime Companion (1989)
American and French films, the first with the theme. “Longtime Companion” by Norman René is considered to be one of the first productions, which described the HI-Virus triggered a disease. It is the story of eight gay New York friends at the beginning of the 1980s. A theme of the film: the displacement of AIDS in individuals and in society.
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Live and love with HIV: films on the subject of AIDSAutobiographical: Wild Nights (1992)
The theme of the displacement of AIDS, it is also in “Wild nights”. The French Director and starring Cyril Collard, had published his auto-biographically colored novel in 1989, and three years later from the fabric of a Film. In the title role Collard, plays a Bisexual who has no consideration for himself and his Partner. Collard died in 1993.
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Live and love with HIV: films on the subject of AIDSOscar Decorated: Philadelphia (1993)
Jonathan Demme’s Film “Philadelphia” was the first major Hollywood production that AIDS has brought to a wide audience on the screen. Tom Hanks plays a lawyer whose position is terminated because he is ill. In court he wants to sit down to the Weir. The Film is melodramatic and sentimental, but very effectively staged. AIDS was now arrived in the big Hollywood movies.
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Live and love with HIV: films on the subject of AIDSSemidoku fragmentary: …and life goes on (1993)
Philadelphia was in the style of big Hollywood movies are staged, dam of in the same year launched “…and the life goes on a ride” by Roger Spottiswoode another way. The movie tried to use the documentary resources, the spread of the disease to many different locations. The young AIDS researcher Dr. Don Francis, played by Matthew Modine.
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Live and love with HIV: films on the subject of AIDSControversial: Kids (1995)
With documentary resources, the movie “Kids”, which was created two years later worked. Director Larry Clark designed the Panorama of a youth culture in New York in the 1990s. Sex is one of the main topics of the young girls and boys, the subject of AIDS. Controversial the Film was, because he developed with underage performers to very drastic scenes.
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Live and love with HIV: films on the subject of AIDSMelodramatic: All about my mother (1999)
Spain Star Director Pedro Almodóvar told in 1999, in the for him typical style of life, Suffering and the love of a handful of protagonists in Madrid and Barcelona. “All about my mother” is a Melodrama with a lot of feeling and Emotion, gender roles, and social prejudices. Also in “All about my mother” plays the theme of AIDS a Central role.
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Live and love with HIV: films on the subject of AIDSReview: We were the witnesses (2007)
In the early 80s, the Frenchman André Téchiné looked back in, “We were witnesses.” In France, the disease spreads, the protagonists, the Téchiné presents the viewer will be confronted in different situations with AIDS. “We are witnesses” were not celebrated at the Berlinale for the Premiere, but managed, despite Stars like Emmanuelle Béart the jump in the German cinemas.
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Live and love with HIV: films on the subject of AIDSAIDS Global: Same Same But Different (2009)
The German cinema dealt with AIDS. Rosa von Praunheim, the 1986 fact, in typical anarchist fashion with “A Virus knows no morals” is very early and first. Director Detlef Buck turned in 2009, the movie “Same Same But Different”, which shows a love between a young German (David Kross, and our image) and a Cambodian prostitute.
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Live and love with HIV: films on the subject of AIDSActors Movie: Dallas Buyers Club (2014)
Had great success Jean four years ago, the Film “Dallas Buyers Club” of the canadian Director-Marc Vallée. Matthew McConaughey (R) and Jared Leto Shine as two HIV-infected protagonists, who strive in the America of the 1980s, effective AIDS drugs. For the two actors, the Oscars 2014 awards for best male performer.